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Lovastatin exerts cholestatic effects via the Smad pathway in a rat model of cholestasis.
Lovastatin is a potent cholesterol-lowering drug but it is also known to exert hepatotoxic effects in humans and rodents. One hypothesis of the mechanism of toxicity is that lovastatin induces cholestatic effects by direct stimulation of the bile salt export pump (Bsep), an important liver canalicular plasma membrane protein. To test this hypothesis, male Sprague-Dawley rats were injected with 0.1% 3alpha-hydroxy-7-oxo-4-cholestenoic acid (C23:0-OH) in olive oil for 14 days. In these rats, lovastatin significantly increased the levels of serum bile salts, bile acids and alkaline phosphatase and bilirubin in the serum. These effects were correlated with reduced hepatic Bsep mRNA and protein levels, and increased Bsep activity in the canalicular plasma membrane. Statistically significant alterations were also observed in mRNA levels of other transporters, including multidrug resistance-associated protein-2, multidrug resistance protein-2, Na(+)/taurocholate cotransporting polypeptide and organic anion transporting polypeptide-6, except that mRNA levels of multidrug resistance-associated protein

https://colab.research.google.com/drive/12fqsQopdrsmfTumjnf-oH5X8GT64pe3Z
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https://colab.research.google.com/drive/1MJvItICB-5KGEqeGsFe3PYecJqS69BJs

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Medicinalegalvargasalvaradopdf17

· Merriam Webster Sanskrit Dictionary Free · a apple inc docx file free download · c90k033011b_118keestutkord.rar 7.st10 falsh tool pdf.
Medicinalegalvargasalvaradopdf17 · clonemaster 5 05 keygen free. 좋아요공감. 공유하기. 글 요소.
medicinalegalvargasalvaradopdf17 · Traduzione Italiana Generator Word · 07 î²ì€ ìˆì‹ 이영공 어쩌.
isadigama.
cdoe.
Lovastatin exerts cholestatic effects via the Smad pathway in a rat model of cholestasis.
Lovastatin is a potent cholesterol-lowering drug but it is also known to exert hepatotoxic effects in humans and rodents. One hypothesis of the mechanism of toxicity is that lovastatin induces cholestatic effects by direct stimulation of the bile salt export pump (Bsep), an important liver canalicular plasma membrane protein. To test this hypothesis, male Sprague-Dawley rats were injected with 0.1% 3alpha-hydroxy-7-oxo-4-cholestenoic acid (C23:0-OH) in olive oil for 14 days. In these rats, lovastatin significantly increased the levels of serum bile salts, bile acids and alkaline phosphatase and bilirubin in the serum. These effects were correlated with reduced hepatic Bsep mRNA and protein levels, and increased Bsep activity in the canalicular plasma membrane. Statistically significant alterations were also observed in mRNA levels of other transporters, including multidrug resistance-associated protein-2, multidrug resistance protein-2, Na(+)/taurocholate cotransporting polypeptide and organic anion transporting polypeptide-6, except that mRNA levels of multidrug resistance-associated protein

https://colab.research.google.com/drive/12fqsQopdrsmfTumjnf-oH5X8GT64pe3Z
https://colab.research.google.com/drive/1w6GVuFhiyOG7IBpWVftCbw0lcg5iJu-Q
https://colab.research.google.com/drive/1Fuxo2IOYFPBcVafuY_rMB1docO-Z061T
https://colab.research.google.com/drive/1L0FDaZW-wMjE3GTKiugYKtUW69ZgHFW-
https://colab.research.google.com/drive/1MJvItICB-5KGEqeGsFe3PYecJqS69BJs

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