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A: The question is How to let an exe run on a remote machine? the answer is PEXEC. Quantitative structure-activity relationships of fatty acid amide hydrolase (FAAH) inhibition. The enzyme fatty acid amide hydrolase (FAAH) hydrolyzes all fatty acid amides, including anandamide (arachidonylethanolamide; AEA), prostaglandin ethanolamide, and N-acylethanolamines, terminating their functional signaling. This enzyme may play an important role in regulating brain cannabinoid/anandamide receptors, and the levels of FAAH-derived inhibitors and agonists may influence neurotransmission. In the present study, quantitative structure-activity relationships (QSARs) for FAAH inhibition were constructed to facilitate the design of inhibitors for this enzyme. Initially, 1000 test analogues were evaluated, which led to the development of a method for structural alignment of compounds, and additional compounds were evaluated for in vitro FAAH inhibition. The potential contribution of carbon electronic and steric effects to inhibitory potency was examined and several new hydrolysis-resistant inhibitors identified. Chemotype- and conformation-dependent effects on potency were then examined. Inhibition of FAAH was found to be conformation dependent, with several new hydroxamate-based inhibitors being identified that provided striking selectivity for the enzyme. Significant steric and electronic effects were observed with conformationally sensitive hydroxamate inhibitors, thus suggesting potential spatial overlap between the ligand and the enzyme as the basis for the observed selectivity. A molecular dynamics simulation was then performed to examine the potential basis for the observed selectivity. On the basis of the present data, several conclusions can be drawn: (1) conformationally sensitive inhibitors can be designed to selectively bind and inhibit FAAH; (2) hydrophobic and electrostatic interactions are of importance, although for hydrophilic inhibitors it is suggested that both properties are of importance; and (3) a small hydrophobic site was identified that may be able to modulate the binding and/or inhibitory potency of inhibitors. MILWAUKEE — Law enforcement sources tell FOX6 News that one of the two people shot and killed last night at a Milwaukee music venue was a gunshot victim. According to Milwaukee Police Chief Ed Flynn, the shooting victim was killed near Milwaukee Repertory Theater on the City’s 3rd Street.

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